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Clinic and Polyclinic for Oral and Maxillofacial Surgery

Research

AG Morsczeck

Director:

  • Prof. Dr. Christian Morsczeck

Staff:

  • Anja Reck, biotechnology assistant (BTA)

Our research group is studying stem cells that can be isolated from the dental follicle (DFSCs). The dental follicle is a tissue of the tooth germ, from which the periodontium is formed. DFSCs possess a differentiation potential for cells of the periodontium and especially for bio-mineralising cells. In our projects, we are examining the molecular mechanisms of DFSCs during osteogenic differentiation to better understand and control the formation of osteoblasts from DFSCs. This is an important prerequisite for stem cell-based regeneration of bones.

In order to be able to use DFSCs in a cell therapy in the future, these must be propagated ex vivo. However, due to cellular senescence, propagation of somatic stem cells is limited, which can substantially restrict future cell therapies with DFSCs. Therefore, our research group is exploring which exogeneous factors and cellular signalling pathways are involved with the induction of senescence in DFSCs. We hope that our findings lead to the development of new cell culture strategies that suppress the senescence in DFSCs.

  • Selected publications (since 2012)
    • Morsczeck C, Reichert TE. The dexamethasone induced osteogenic differentiation of dental follicle cells. Histol Histopathol. 2017 (in press)
    • Morsczeck C, Reck A, Beck HC. The hedgehog-signaling pathway is repressed during the osteogenic differentiation of dental follicle cells. Mol Cell Biochem. 2017 Apr;428(1-2):79-86.
    •  Nayak A, Reck A, Morsczeck C, Müller S. Flightless-I governs cell fate by recruiting the SUMO isopeptidase SENP3 to distinct HOX genes. Epigenetics Chromatin. 2017 Mar 23;10:15.
    • Klingelhöffer C, Codrin C, Ettl T, Reichert T, Morsczeck C. miRNA-101 supports the osteogenic differentiation in human dental follicle cells. Arch Oral Biol. 2016 Dec;72:47-50.
    • Morsczeck C, Gresser J, Ettl T. The induction of cellular senescence in dental follicle cells inhibits the osteogenic differentiation. Mol Cell Biochem. 2016 Jun;417(1-2):1-6.
    • Prateeptongkum E, Klingelhöffer C, Müller S, Ettl T, Morsczeck C. Characterization of progenitor cells and stem cells from the periodontal ligament tissue derived from a single person. J Periodontal Res. 2016 Apr;51(2):265-72.
    • Morsczeck C. Molecular mechanisms in dental follicle precursor cells during the osteogenic differentiation. Histol Histopathol. 2015 Oct;30(10):1161-9.
    • Viale-Bouroncle S, Klingelhöffer C, Ettl T, Morsczeck C. The AKT signaling pathway sustains the osteogenic differentiation in human dental follicle cells. Mol Cell Biochem. 2015 Aug;406(1-2):199-204.
    • Viale-Bouroncle S, Klingelhöffer C, Ettl T, Reichert TE, Morsczeck C. A protein kinase A (PKA)/β-catenin pathway sustains the BMP2/DLX3-induced osteogenic differentiation in dental follicle cells (DFCs). Cell Signal. 2015 Mar;27(3):598-605.
    • Viale-Bouroncle S, Klingelhöffer C, Ettl T, Morsczeck C. The WNT inhibitor APCDD1 sustains the expression of β-catenin during the osteogenic differentiation of human dental follicle cells. Biochem Biophys Res Commun. 2015 Feb 13;457(3):314-7.
    • Press T, Viale-Bouroncle S, Felthaus O, Gosau M, Morsczeck C. EGR1 supports the osteogenic differentiation of dental stem cells. Int Endod J. 2015 Feb;48(2):185-92.
    • Viale-Bouroncle S, Gosau M, Morsczeck C. Collagen I induces the expression of alkaline phosphatase and osteopontin via independent activations of FAK and ERK signalling pathways. Arch Oral Biol. 2014 Dec;59(12):1249-55.
    • Felthaus O, Gosau M, Klein S, Prantl L, Reichert TE, Schmalz G, Morsczeck C. Dexamethasone-related osteogenic differentiation of dental follicle cells depends on ZBTB16 but not Runx2. Cell Tissue Res. 2014 Sep;357(3):695-705.
    • Nayak A, Viale-Bouroncle S, Morsczeck C, Muller S. The SUMO-specific isopeptidase SENP3 regulates MLL1/MLL2 methyltransferase complexes and controls osteogenic differentiation. Mol Cell. 2014 Jul 3;55(1):47-58.
    • Viale-Bouroncle S, Gosau M, Morsczeck C. Laminin regulates the osteogenic differentiation of dental follicle cells via integrin-α2/-β1 and the activation of the FAK/ERK signaling pathway. Cell Tissue Res. 2014 Jul;357(1):345-54.
    • Felthaus O, Gosau M, Morsczeck C. ZBTB16 induces osteogenic differentiation marker genes in dental follicle cells independent from RUNX2. J Periodontol. 2014 May;85(5):e144-51.
    • Felthaus O, Gosau M, Ettl T, Prantl L, Morsczeck C. Migration of human dental follicle cells in vitro. J Periodontal Res. 2014 Apr;49(2):205-12.
    • Viale-Bouroncle S, Gosau M, Morsczeck C. NOTCH1 signaling regulates the BMP2/DLX-3 directed osteogenic differentiation of dental follicle cells. Biochem Biophys Res Commun. 2014 Jan 10;443(2):500-4.
    • Viale-Bouroncle S, Buergers R, Morsczeck C, Gosau M. β-Tricalcium phosphate induces apoptosis on dental follicle cells. Calcif Tissue Int. 2013 May;92(5):412-7.
    • Viale-Bouroncle S, Gosau M, Küpper K, Möhl C, Brockhoff G, Reichert TE, Schmalz G, Ettl T, Morsczeck C. Rigid matrix supports osteogenic differentiation of stem cells from human exfoliated deciduous teeth (SHED). Differentiation. 2012 Dec;84(5):366-70.
    • Morsczeck C. Transgene-free induced pluripotent dental stem cells for neurogenic differentiation. Stem Cell Res Ther. 2012 Nov 22;3(6):46.
    • Viale-Bouroncle S, Felthaus O, Schmalz G, Brockhoff G, Reichert TE, Morsczeck C. The transcription factor DLX3 regulates the osteogenic differentiation of human dental follicle precursor cells. Stem Cells Dev. 2012 Jul 20;21(11):1936-47.