1. Mack, M, Riethmüller, G and Kufer, P. A small bispecific antibody construct expressed as a functional single-chain molecule with high tumor cell cytotoxicity. Proc Natl Acad Sci USA 1995. 92: 7021-7025.
2. Mack, M, Gruber, R, Schmidt, S, Riethmüller, G and Kufer, P. Biologic properties of a bispecific single-chain antibody directed against 17-1A (EpCAM) and CD3: tumor cell-dependent T cell stimulation and cytotoxic activity. J Immunol 1997. 158: 3965-3970.
3. Mack, M, Luckow, B, Nelson, PJ, Cihak, J, Simmons, G, Clapham, PR, Signoret, N, Marsh, M, Stangassinger, M, Borlat, F, Wells, TN, Schlöndorff, D and Proudfoot, AE. Aminooxypentane-RANTES induces CCR5 internalization but inhibits recycling: a novel inhibitory mechanism of HIV infectivity. J Exp Med 1998. 187: 1215-1224.
4. Mack, M, Brühl, H, Gruber, R, Jaeger, C, Cihak, J, Eiter, V, Plachy, J, Stangassinger, M, Uhlig, K, Schattenkirchner, M and Schlöndorff, D. Predominance of mononuclear cells expressing the chemokine receptor CCR5 in synovial effusions of patients with different forms of arthritis. Arthritis Rheum 1999. 42: 981-988.
5. Mack, M*, Segerer, S*, Regele, H, Kerjaschki, D and Schlöndorff, D. Expression of the C-C chemokine receptor 5 in human kidney diseases. Kidney Int 1999. 56: 52-64. *equal contribution
6. Mack, M*, Elsner, J*, Brühl, H, Dulkys, Y, Kimmig, D, Simmons, G, Clapham, PR, Schlöndorff, D, Kapp, A, Wells, TN and Proudfoot, AE. Differential activation of CC chemokine receptors by AOP-RANTES. J Biol Chem 2000. 275: 7787-7794. *equal contribution
7. Mack, M, Kleinschmidt, A, Brühl, H, Klier, C, Nelson, PJ, Cihak, J, Plachy, J, Stangassinger, M, Erfle, V and Schlöndorff, D. Transfer of the chemokine receptor CCR5 between cells by membrane-derived microparticles: a mechanism for cellular human immunodeficiency virus 1 infection. Nature Medicine 2000. 6: 769-775.
8. Mack, M and Schlöndorff, D. Downmodulation and recycling of chemokine receptors. Methods Mol Biol 2000. 138: 191-195.
9. Pfirstinger, J and Mack, M. Expression of chemokines in the periplasmic space of E. coli. Methods Mol Biol 2000. 138: 41-45.
10. Brühl, H, Cihak, J, Stangassinger, M, Schlöndorff, D and Mack, M. Depletion of CCR5-expressing cells with bispecific antibodies and chemokine toxins: a new strategy in the treatment of chronic inflammatory diseases and HIV. J Immunol 2001. 166: 2420-2426.
11. Brühl, H, Wagner, K, Kellner, H, Schattenkirchner, M, Schlöndorff, D and Mack, M. Surface expression of CC- and CXC-chemokine receptors on leucocyte subsets in inflammatory joint diseases. Clin Exp Immunol 2001. 126: 551-559.
12. Mack, M, Cihak, J, Simonis, C, Luckow, B, Proudfoot, AE, Plachy, J, Brühl, H, Frink, M, Anders, HJ, Vielhauer, V, Pfirstinger, J, Stangassinger, M and Schlöndorff, D. Expression and characterization of the chemokine receptors CCR2 and CCR5 in mice. J Immunol 2001. 166: 4697-4704.
13. Blanpain, C, Vanderwinden, JM, Cihak, J, Wittamer, V, Le Poul, E, Issafras, H, Stangassinger, M, Vassart, G, Marullo, S, Schlöndorff, D, Parmentier, M and Mack, M. Multiple active states and oligomerization of CCR5 revealed by functional properties of monoclonal antibodies. Mol Biol Cell 2002. 13: 723-737.
14. Mack, M, Pfirstinger, J, Weber, C, Weber, KS, Nelson, PJ, Rupp, T, Maletz, K, Brühl, H and Schlöndorff, D. Chondroitin sulfate A released from platelets blocks RANTES presentation on cell surfaces and RANTES-dependent firm adhesion of leukocytes. Eur J Immunol 2002. 32: 1012-1020.
15. Brühl, H, Cohen, CD, Linder, S, Kretzler, M, Schlöndorff, D and Mack, M. Post-translational and cell type-specific regulation of CXCR4 expression by cytokines. Eur J Immunol 2003. 33: 3028-3037.
16. Vielhauer, V, Anders, HJ, Perez de Lema, G, Luckow, B, Schlöndorff, D and Mack, M. Phenotyping renal leukocyte subsets by four-color flow cytometry: characterization of chemokine receptor expression. Nephron Exp Nephrol 2003. 93: 63-71.
17. Brühl, H, Cihak, J, Schneider, MA, Plachy, J, Rupp, T, Wenzel, I, Shakarami, M, Milz, S, Ellwart, JW, Stangassinger, M, Schlöndorff, D and Mack, M. Dual role of CCR2 during initiation and progression of collagen-induced arthritis: evidence for regulatory activity of CCR2+ T cells. J Immunol 2004. 172: 890-898.
18. Mack, M, Pfirstinger, J, Haas, J, Nelson, PJ, Kufer, P, Riethmüller, G and Schlöndorff, D. Preferential Targeting of CD4-CCR5 Complexes with Bifunctional Inhibitors: A Novel Approach to Block HIV-1 Infection. J Immunol 2005. 175: 7586-7593.
19. Mack, M, Schneider, MA, Moll, C, Cihak, J, Brühl, H, Ellwart, JW, Hogarth, MP, Stangassinger, M and Schlöndorff, D. Identification of antigen-capturing cells as basophils. J Immunol 2005. 174: 735-741.
20. Schneider, MA, Brühl, H, Wechselberger, A, Cihak, J, Stangassinger, M, Schlöndorff, D and Mack, M. In vitro and in vivo properties of a dimeric bispecific single-chain antibody IgG-fusion protein for depletion of CCR2+ target cells in mice. Eur J Immunol 2005. 35: 987-995.
21. Köppler, B, Cohen, C, Schlöndorff, D and Mack, M. Differential mechanisms of microparticle transfer to B cells and monocytes: anti-inflammatory properties of microparticles. Eur J Immunol 2006. 36: 648-660.
22. Brühl, H, Cihak, J, Plachy, J, Kunz-Schughart, L, Niedermeier, M, Denzel, A, Rodriguez Gomez, M, Talke, Y, Luckow, B, Stangassinger, M and Mack, M. Targeting of Gr-1+,CCR2+ monocytes in collagen-induced arthritis. Arthritis Rheum 2007. 56: 2975-2985.
23. Weingart, C, Nelson, PJ, Kramer, BK and Mack, M. Dose dependent effects of platelet derived chondroitinsulfate A on the binding of CCL5 to endothelial cells. BMC Immunol 2008. 9: 72.
24. Denzel, A, Maus, U, Rodriguez Gomez, M, Moll, C, Niedermeier, M, Winter, C, Maus, R, Hollingshead, S, Briles, DE, Kunz-Schughart, L, Talke, Y and Mack, M. Basophils enhance immunological memory responses. Nature Immunology 2008. 9:733-742.
25. Bruhl, H, Cihak, J, Niedermeier, M, Denzel, A, Rodriguez Gomez, M, Talke, Y, Goebel, N, Plachy, J, Stangassinger, M and Mack, M. Important role of interleukin-3 in the early phase of collagen-induced arthritis. Arthritis Rheum 2009. 60: 1352-1361.
26. Niedermeier, M, Reich, B, Rodrigues Gomez, M, Denzel, A, Schmidbauer, K, Goebel, N, Talke, Y, Schweda, F and Mack, M. CD4+ T cells control the differentiation of Gr1+ monocytes into fibrocytes. Proc Natl Acad Sci U S A 2009. 106:17892-17897.
27. Rodriguez Gomez, M, Talke, Y, Goebel, N, Hermann, F, Reich, B and Mack, M. Basophils support the survival of plasma cells in mice. J Immunol 2010. 185: 7180-7185.
28. Reich, B, Schmidbauer, K, Rodriguez Gomez, M, Johannes Hermann, F, Gobel, N, Bruhl, H, Ketelsen, I, Talke, Y and Mack, M. Fibrocytes develop outside the kidney but contribute to renal fibrosis in a mouse model. Kidney Int 2013. 84: 78-89.
29. Rodrigues Gomez, M, Talke, Y, Hofmann, C, Ketelsen, I, Hermann, F, Reich, B, Goebel, N, Schmidbauer, K, Dunger, N, Brühl, H, Renner, K, Syed, S-N and Mack, M. Basophils control T cell Responses and limit Disease Activity in Experimental Murine Colitis. Mucosal Immunol 2014. 7: 188-199.
30. Bruhl, H, Cihak, J, Goebel, N, Talke, Y, Renner, K, Hermann, F, Rodriguez-Gomez, M, Reich, B, Plachy, J, Stangassinger, M and Mack, M. Chondroitin sulfate activates B cells in vitro, expands CD138+ cells in vivo, and interferes with established humoral immune responses. J Leukoc Biol 2014. 96: 65-72.
31. Bruhl, H, Cihak, J, Talke, Y, Rodriguez Gomez, M, Hermann, F, Goebel, N, Renner, K, Plachy, J, Stangassinger, M, Aschermann, S, Nimmerjahn, F and Mack, M. B-cell inhibition by cross-linking CD79b is superior to B-cell depletion with anti-CD20 antibodies in treating murine collagen-induced arthritis. Eur J Immunol 2015. 45: 705-715.
32. Hermann, FJ, Rodriguez Gomez, M, Doser, K, Edinger, M, Hoffmann, P, Schiechl, G, Talke, Y, Gobel, N, Schmidbauer, K, Syed, SN, Bruhl, H and Mack, M. Basophils inhibit proliferation of CD4(+) T cells in autologous and allogeneic mixed lymphocyte reactions and limit disease activity in a murine model of graft versus host disease. Immunology 2015. 145: 202-212.
33. Renner, K, Hermann, FJ, Schmidbauer, K, Talke, Y, Rodriguez Gomez, M, Schiechl, G, Schlossmann, J, Bruhl, H, Anders, HJ and Mack, M. IL-3 contributes to development of lupus nephritis in MRL/lpr mice. Kidney Int 2015. 88: 1088-1098.
34. Schiechl, G, Hermann, FJ, Rodriguez Gomez, M, Kutzi, S, Schmidbauer, K, Talke, Y, Neumayer, S, Goebel, N, Renner, K, Bruhl, H, Karasuyama, H, Obata-Ninomiya, K, Utpatel, K, Evert, M, Hirt, SW, Geissler, EK, Fichtner-Feigl, S and Mack, M. Basophils trigger fibroblast activation in cardiac allograft fibrosis development. Am J Transplant 2016;16(9):2574-88.
35. Renner, K, Hellerbrand, S, Hermann, F, Riedhammer, C, Talke, Y, Schiechl, G, Gomez, MR, Kutzi, S, Halbritter, D, Goebel, N, Brühl, H, Weissert, R and Mack, M. IL-3 promotes the development of experimental autoimmune encephalitis. JCI Insight 2016 Oct 6;1(16):e87157.
36. Oppermann, M, Mack, M, Proudfoot, AE and Olbrich, H. Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus. J Biol Chem 1999. 274: 8875-8885.
37. Eitner, F, Cui, Y, Hudkins, KL, Stokes, MB, Segerer, S, Mack, M, Lewis, PL, Abraham, AA, Schlöndorff, D, Gallo, G, Kimmel, PL and Alpers, CE. Chemokine receptor CCR5 and CXCR4 expression in HIV-associated kidney disease. J Am Soc Nephrol 2000. 11: 856-867.
38. Segerer, S, Cui, Y, Hudkins, KL, Goodpaster, T, Eitner, F, Mack, M, Schlöndorff, D and Alpers, CE. Expression of the chemokine monocyte chemoattractant protein-1 and its receptor chemokine receptor 2 in human crescentic glomerulonephritis. J Am Soc Nephrol 2000. 11: 2231-2242.
39. Segerer, S, Regele, H, Mack, M, Kain, R, Cartron, JP, Colin, Y, Kerjaschki, D and Schlöndorff, D. The Duffy antigen receptor for chemokines is up-regulated during acute renal transplant rejection and crescentic glomerulonephritis. Kidney Int 2000. 58: 1546-1556.
40. Signoret, N, Pelchen-Matthews, A, Mack, M, Proudfoot, AE and Marsh, M. Endocytosis and recycling of the HIV coreceptor CCR5. J Cell Biol 2000. 151: 1281-1294.
41. Steppich, B, Dayyani, F, Gruber, R, Lorenz, R, Mack, M and Ziegler-Heitbrock, HW. Selective mobilization of CD14(+)CD16(+) monocytes by exercise. Am J Physiol Cell Physiol 2000. 279: C578-586.
42. Weber, C, Belge, KU, von Hundelshausen, P, Draude, G, Steppich, B, Mack, M, Frankenberger, M, Weber, KS and Ziegler-Heitbrock, HW. Differential chemokine receptor expression and function in human monocyte subpopulations. J Leukoc Biol 2000. 67: 699-704.
43. Blanpain, C, Buser, R, Power, CA, Edgerton, M, Buchanan, C, Mack, M, Simmons, G, Clapham, PR, Parmentier, M and Proudfoot, AE. A chimeric MIP-1alpha/RANTES protein demonstrates the use of different regions of the RANTES protein to bind and activate its receptors. J Leukoc Biol 2001. 69: 977-985.
44. Huo, Y, Weber, C, Forlow, SB, Sperandio, M, Thatte, J, Mack, M, Jung, S, Littman, DR and Ley, K. The chemokine KC, but not monocyte chemoattractant protein-1, triggers monocyte arrest on early atherosclerotic endothelium. J Clin Invest 2001. 108: 1307-1314.
45. Kraft, K, Olbrich, H, Majoul, I, Mack, M, Proudfoot, A and Oppermann, M. Characterization of sequence determinants within the carboxyl-terminal domain of chemokine receptor CCR5 that regulate signaling and receptor internalization. J Biol Chem 2001. 276: 34408-34418.
46. Maletz, K, Kufer, P, Mack, M, Raum, T, Pantel, K, Riethmüller, G and Gruber, R. Bispecific single-chain antibodies as effective tools for eliminating epithelial cancer cells from human stem cell preparations by redirected cell cytotoxicity. Int J Cancer 2001. 93: 409-416.
47. Martin, K, Heinzlmann, M, Borchers, R, Mack, M, Loeschke, K and Folwaczny, C. Delta 32 mutation of the chemokine-receptor 5 gene in inflammatory bowel disease. Clin Immunol 2001. 98: 18-22.
48. Segerer, S, Cui, Y, Eitner, F, Goodpaster, T, Hudkins, KL, Mack, M, Cartron, JP, Colin, Y, Schlöndorff, D and Alpers, CE. Expression of chemokines and chemokine receptors during human renal transplant rejection. Am J Kidney Dis 2001. 37: 518-531.
49. Vielhauer, V, Anders, HJ, Mack, M, Cihak, J, Strutz, F, Stangassinger, M, Luckow, B, Gröne, HJ and Schlöndorff, D. Obstructive nephropathy in the mouse: progressive fibrosis correlates with tubulointerstitial chemokine expression and accumulation of CC chemokine receptor 2- and 5-positive leukocytes. J Am Soc Nephrol 2001. 12: 1173-1187.
50. Anders, HJ, Vielhauer, V, Frink, M, Linde, Y, Cohen, CD, Blattner, SM, Kretzler, M, Strutz, F, Mack, M, Gröne, HJ, Onuffer, J, Horuk, R, Nelson, PJ and Schlöndorff, D. A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral ureter ligation. J Clin Invest 2002. 109: 251-259.
51. Banas, B, Wörnle, M, Berger, T, Nelson, PJ, Cohen, CD, Kretzler, M, Pfirstinger, J, Mack, M, Lipp, M, Gröne, HJ and Schlöndorff, D. Roles of SLC/CCL21 and CCR7 in human kidney for mesangial proliferation, migration, apoptosis, and tissue homeostasis. J Immunol 2002. 168: 4301-4307.
52. Kivisakk, P, Trebst, C, Liu, Z, Tucky, BH, Sorensen, TL, Rudick, RA, Mack, M and Ransohoff, RM. T-cells in the cerebrospinal fluid express a similar repertoire of inflammatory chemokine receptors in the absence or presence of CNS inflammation: implications for CNS trafficking. Clin Exp Immunol 2002. 129: 510-518.
53. Maus, U, von Grote, K, Kuziel, WA, Mack, M, Miller, EJ, Cihak, J, Stangassinger, M, Maus, R, Schlöndorff, D, Seeger, W and Lohmeyer, J. The role of CC chemokine receptor 2 in alveolar monocyte and neutrophil immigration in intact mice. Am J Respir Crit Care Med 2002. 166: 268-273.
54. Maus, UA, Koay, MA, Delbeck, T, Mack, M, Ermert, M, Ermert, L, Blackwell, TS, Christman, JW, Schlöndorff, D, Seeger, W and Lohmeyer, J. Role of resident alveolar macrophages in leukocyte traffic into the alveolar air space of intact mice. Am J Physiol Lung Cell Mol Physiol 2002. 282: L1245-1252.
55. Segerer, S, Hughes, E, Hudkins, KL, Mack, M, Goodpaster, T and Alpers, CE. Expression of the fractalkine receptor (CX3CR1) in human kidney diseases. Kidney Int 2002. 62: 488-495.
56. Belnoue, E, Costa, FT, Vigario, AM, Voza, T, Gonnet, F, Landau, I, Van Rooijen, N, Mack, M, Kuziel, WA and Renia, L. Chemokine receptor CCR2 is not essential for the development of experimental cerebral malaria. Infect Immun 2003. 71: 3648-3651.
57. Belnoue, E, Kayibanda, M, Deschemin, JC, Viguier, M, Mack, M, Kuziel, WA and Renia, L. CCR5 deficiency decreases susceptibility to experimental cerebral malaria. Blood 2003. 101: 4253-4259.
58. Dayyani, F, Belge, KU, Frankenberger, M, Mack, M, Berki, T and Ziegler-Heitbrock, L. Mechanism of glucocorticoid-induced depletion of human CD14+CD16+ monocytes. J Leukoc Biol 2003. 74: 33-39.
59. Ghoreschi, K, Thomas, P, Breit, S, Dugas, M, Mailhammer, R, Van Eden, W, Van Der Zee, R, Biedermann, T, Prinz, J, Mack, M, Mrowietz, U, Christophers, E, Schlöndorff, D, Plewig, G, Sander, CA and Röcken, M. Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease. Nature Med 2003. 9: 40-46.
60. Kivisakk, P, Liu, Z, Trebst, C, Tucky, B, Wu, L, Stine, J, Mack, M, Rudick, RA, Campbell, JJ and Ransohoff, RM. Flow cytometric analysis of chemokine receptor expression on cerebrospinal fluid leukocytes. Methods 2003. 29: 319-325.
61. Lamprecht, P, Brühl, H, Erdmann, A, Holl-Ulrich, K, Csernok, E, Seitzer, U, Mack, M, Feller, AC, Reinhold-Keller, E, Gross, WL and Müller, A. Differences in CCR5 expression on peripheral blood CD4+CD28- T-cells and in granulomatous lesions between localized and generalized Wegener's granulomatosis. Clin Immunol 2003. 108: 1-7.
62. Maus, UA, Waelsch, K, Kuziel, WA, Delbeck, T, Mack, M, Blackwell, TS, Christman, JW, Schlöndorff, D, Seeger, W and Lohmeyer, J. Monocytes are potent facilitators of alveolar neutrophil emigration during lung inflammation: role of the CCL2-CCR2 axis. J Immunol 2003. 170: 3273-3278.
63. Schuh, JM, Blease, K, Brühl, H, Mack, M and Hogaboam, CM. Intrapulmonary targeting of RANTES/CCL5-responsive cells prevents chronic fungal asthma. Eur J Immunol 2003. 33: 3080-3090.
64. Eis, V, Luckow, B, Vielhauer, V, Siveke, JT, Linde, Y, Segerer, S, De Lema, GP, Cohen, CD, Kretzler, M, Mack, M, Horuk, R, Murphy, PM, Gao, JL, Hudkins, KL, Alpers, CE, Grone, HJ, Schlöndorff, D and Anders, HJ. Chemokine receptor CCR1 but not CCR5 mediates leukocyte recruitment and subsequent renal fibrosis after unilateral ureteral obstruction. J Am Soc Nephrol 2004. 15: 337-347.
65. Feterowski, C, Mack, M, Weighardt, H, Bartsch, B, Kaiser-Moore, S and Holzmann, B. CC chemokine receptor 2 regulates leukocyte recruitment and IL-10 production during acute polymicrobial sepsis. Eur J Immunol 2004.
66. Johnson, Z, Kosco-Vilbois, MH, Herren, S, Cirillo, R, Muzio, V, Zaratin, P, Carbonatto, M, Mack, M, Smailbegovic, A, Rose, M, Lever, R, Page, C, Wells, TN and Proudfoot, AE. Interference with heparin binding and oligomerization creates a novel anti-inflammatory strategy targeting the chemokine system. J Immunol 2004. 173: 5776-5785.
67. Maus, UA, Srivastava, M, Paton, JC, Mack, M, Everhart, MB, Blackwell, TS, Christman, JW, Schlöndorff, D, Seeger, W and Lohmeyer, J. Pneumolysin-induced lung injury is independent of leukocyte trafficking into the alveolar space. J Immunol 2004. 173: 1307-1312.
68. Panzer, U, Reinking, RR, Steinmetz, OM, Zahner, G, Sudbeck, U, Fehr, S, Pfalzer, B, Schneider, A, Thaiss, F, Mack, M, Conrad, S, Huland, H, Helmchen, U and Stahl, RA. CXCR3 and CCR5 Positive T-Cell Recruitment in Acute Human Renal Allograft Rejection. Transplantation 2004. 78: 1341-1350.
69. Peters, W, Cyster, JG, Mack, M, Schlöndorff, D, Wolf, AJ, Ernst, JD and Charo, IF. CCR2-dependent trafficking of F4/80dim macrophages and CD11cdim/intermediate dendritic cells is crucial for T cell recruitment to lungs infected with Mycobacterium tuberculosis. J Immunol 2004. 172: 7647-7653.
70. Segerer, S, Banas, B, Wörnle, M, Schmid, H, Cohen, CD, Kretzler, M, Mack, M, Kiss, E, Nelson, PJ, Schlöndorff, D and Gröne, HJ. CXCR3 is involved in tubulointerstitial injury in human glomerulonephritis. Am J Pathol 2004. 164: 635-649.
71. Brühl, H, Vielhauer, V, Weiss, M, Mack, M, Schlöndorff, D and Segerer, S. Expression of DARC, CXCR3 and CCR5 in giant cell arteritis. Rheumatology (Oxford) 2005. 44: 309-313.
72. Kantarci, OH, Morales, Y, Ziemer, PA, Hebrink, DD, Mahad, DJ, Atkinson, EJ, Achenbach, SJ, De Andrade, M, Mack, M, Ransohoff, RM, Lassmann, H, Bruck, W, Weinshenker, BG and Lucchinetti, CF. CCR5Delta32 polymorphism effects on CCR5 expression, patterns of immunopathology and disease course in multiple sclerosis. J Neuroimmunol 2005. 169: 137-143.
73. Maus, UA, Wellmann, S, Hampl, C, Kuziel, WA, Srivastava, M, Mack, M, Everhart, MB, Blackwell, TS, Christman, JW, Schlöndorff, D, Bohle, RM, Seeger, W and Lohmeyer, J. CCR2-positive monocytes recruited to inflamed lungs downregulate local CCL2 chemokine levels. Am J Physiol Lung Cell Mol Physiol 2005. 288: L350-358.
74. Xu, H, Manivannan, A, Dawson, R, Crane, IJ, Mack, M, Sharp, P and Liversidge, J. Differentiation to the CCR2+ inflammatory phenotype in vivo is a constitutive, time-limited property of blood monocytes and is independent of local inflammatory mediators. J Immunol 2005. 175: 6915-6923.
75. Crane, IJ, Xu, H, Wallace, C, Manivannan, A, Mack, M, Liversidge, J, Marquez, G, Sharp, PF and Forrester, JV. Involvement of CCR5 in the passage of Th1-type cells across the blood-retina barrier in experimental autoimmune uveitis. J Leukoc Biol 2006. 79: 435-443.
76. Herold, S, von Wulffen, W, Steinmueller, M, Pleschka, S, Kuziel, WA, Mack, M, Srivastava, M, Seeger, W, Maus, UA and Lohmeyer, J. Alveolar epithelial cells direct monocyte transepithelial migration upon influenza virus infection: impact of chemokines and adhesion molecules. J Immunol 2006. 177: 1817-1824.
77. Mahad, D, Callahan, MK, Williams, KA, Ubogu, EE, Kivisakk, P, Tucky, B, Kidd, G, Kingsbury, GA, Chang, A, Fox, RJ, Mack, M, Sniderman, MB, Ravid, R, Staugaitis, SM, Stins, MF and Ransohoff, RM. Modulating CCR2 and CCL2 at the blood-brain barrier: relevance for multiple sclerosis pathogenesis. Brain 2006. 129: 212-223.
78. Resch, M, Banas, B, Endemann, D, Mack, M, Riegger, GA, Grone, HJ and Kramer, BK. Exanthema and acute anuric renal failure. Clin Nephrol 2006. 65: 361-363.
79. Seifarth, C, Mack, M, Steinlicht, S, Hahn, EG and Lohmann, T. Transient chemokine receptor blockade does not prevent, but may accelerate type 1 diabetes in prediabetic NOD mice. Horm Metab Res 2006. 38: 167-171.
80. Stenstad, H, Ericsson, A, Johansson-Lindbom, B, Svensson, M, Marsal, J, Mack, M, Picarella, D, Soler, D, Marquez, G, Briskin, M and Agace, WW. Gut associated lymphoid tissue primed CD4+ T cells display CCR9 dependent and independent homing to the small intestine. Blood 2006. 107: 3447-3454.
81. Weingart, C, Leingartner, T, Bergler, T, Kruger, B, Boger, C, Mack, M, Banas, B and Kramer, BK. Increase in renal vascular resistance after intake of cyclosporin A and tacrolimus and reversal by nitroglycerin spray: a study in patients with stable renal allograft function. Int J Clin Pharmacol Ther 2006. 44: 422-427.
82. Conrad, SM, Strauss-Ayali, D, Field, AE, Mack, M and Mosser, DM. Leishmania-Derived Murine Monocyte Chemoattractant Protein 1 Enhances the Recruitment of a Restrictive Population of CC Chemokine Receptor 2-Positive Macrophages. Infect Immun 2007. 75: 653-665.
83. Maus, UA, Backi, M, Winter, C, Srivastava, M, Schwarz, MK, Ruckle, T, Paton, JC, Briles, D, Mack, M, Welte, T, Maus, R, Bohle, RM, Seeger, W, Rommel, C, Hirsch, E, Lohmeyer, J and Preissner, KT. Importance of Phosphoinositide 3-Kinase {gamma} in the Host Defense Against Pneumococcal Infection. Am J Respir Crit Care Med 2007. 175: 958-966.
84. Quinones, MP, Kalkonde, Y, Estrada, CA, Jimenez, F, Ramirez, R, Mahimainathan, L, Mummidi, S, Choudhury, GG, Martinez, H, Adams, L, Mack, M, Reddick, RL, Maffi, S, Haralambous, S, Probert, L, Ahuja, SK and Ahuja, SS. Role of astrocytes and chemokine systems in acute TNFalpha induced demyelinating syndrome: CCR2-dependent signals promote astrocyte activation and survival via NF-kappaB and Akt. Mol Cell Neurosci 2007.
85. Tacke, F, Alvarez, D, Kaplan, TJ, Jakubzick, C, Spanbroek, R, Llodra, J, Garin, A, Liu, J, Mack, M, van Rooijen, N, Lira, SA, Habenicht, AJ and Randolph, GJ. Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques. J Clin Invest 2007. 117: 185-194.
86. Tsou, CL, Peters, W, Si, Y, Slaymaker, S, Aslanian, AM, Weisberg, SP, Mack, M and Charo, IF. Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites. J Clin Invest 2007. 117: 902-909.
87. Winter, C, Taut, K, Langer, F, Mack, M, Briles, DE, Paton, JC, Maus, R, Srivastava, M, Welte, T and Maus, UA. FMS-Like Tyrosine Kinase 3 Ligand Aggravates the Lung Inflammatory Response to Streptococcus pneumoniae Infection in Mice: Role of Dendritic Cells. J Immunol 2007. 179: 3099-3108.
88. Winter, C, Taut, K, Srivastava, M, Langer, F, Mack, M, Briles, DE, Paton, JC, Maus, R, Welte, T, Gunn, MD and Maus, UA. Lung-specific overexpression of CC chemokine ligand (CCL) 2 enhances the host defense to Streptococcus pneumoniae infection in mice: role of the CCL2-CCR2 axis. J Immunol 2007. 178: 5828-5838.
89. Gupta, S, Fuchs, B, Schulz-Maronde, S, Heitland, A, Escher, SE, Mack, M, Tillmann, HC, Braun, A, Forssmann, WG, Elsner, J and Forssmann, U. Intravascular inactivation of CCR5 by n-Nonanoyl-CC chemokine ligand 14 and inhibition of allergic airway inflammation. J Leukoc Biol 2008. 83: 765-773.
90. Jakubzick, C, Tacke, F, Ginhoux, F, Wagers, AJ, van Rooijen, N, Mack, M, Merad, M and Randolph, GJ. Blood Monocyte Subsets Differentially Give Rise to CD103+ and CD103- Pulmonary Dendritic Cell Populations. J Immunol 2008. 180: 3019-3027.
91. Quinones, MP, Kalkonde, Y, Estrada, CA, Jimenez, F, Ramirez, R, Mahimainathan, L, Mummidi, S, Choudhury, GG, Martinez, H, Adams, L, Mack, M, Reddick, RL, Maffi, S, Haralambous, S, Probert, L, Ahuja, SK and Ahuja, SS. Role of astrocytes and chemokine systems in acute TNFalpha induced demyelinating syndrome: CCR2-dependent signals promote astrocyte activation and survival via NF-kappaB and Akt. Mol Cell Neurosci 2008. 37: 96-109.
92. Mignot, G, Ullrich, E, Bonmort, M, Menard, C, Apetoh, L, Taieb, J, Bosisio, D, Sozzani, S, Ferrantini, M, Schmitz, J, Mack, M, Ryffel, B, Bulfone-Paus, S, Zitvogel, L and Chaput, N. The critical role of IL-15 in the antitumor effects mediated by the combination therapy imatinib and IL-2. J Immunol 2008. 180: 6477-6483.
93. Schroeder, JA, Weingart, C, Coras, B, Hausser, I, Reinhold, S, Mack, M, Seybold, V, Vogt, T, Banas, B, Hofstaedter, F and Kramer, BK. Ultrastructural evidence of dermal gadolinium deposits in a patient with nephrogenic systemic fibrosis and end-stage renal disease. Clin J Am Soc Nephrol 2008. 3: 968-975.
94. Bruhl, H, Mack, M, Niedermeier, M, Lochbaum, D, Scholmerich, J and Straub, RH. Functional expression of the chemokine receptor CCR7 on fibroblast-like synoviocytes. Rheumatology (Oxford) 2008. 47: 1771-1774.
95. Handel, TM, Johnson, Z, Rodrigues, DH, Dos Santos, AC, Cirillo, R, Muzio, V, Riva, S, Mack, M, Deruaz, M, Borlat, F, Vitte, PA, Wells, TN, Teixeira, MM and Proudfoot, AE. An engineered monomer of CCL2 has anti-inflammatory properties emphasizing the importance of oligomerization for chemokine activity in vivo. J Leukoc Biol 2008. 84: 1101-1108.
96. Herold, S, Steinmueller, M, von Wulffen, W, Cakarova, L, Pinto, R, Pleschka, S, Mack, M, Kuziel, WA, Corazza, N, Brunner, T, Seeger, W and Lohmeyer, J. Lung epithelial apoptosis in influenza virus pneumonia: the role of macrophage-expressed TNF-related apoptosis-inducing ligand. J Exp Med 2008. 205: 3065-3077.
97. Mildner, A, Djukic, M, Garbe, D, Wellmer, A, Kuziel, WA, Mack, M, Nau, R and Prinz, M. Ly-6G+CCR2- myeloid cells rather than Ly-6ChighCCR2+ monocytes are required for the control of bacterial infection in the central nervous system. J Immunol 2008. 181: 2713-2722.
98. Varga, G, Ehrchen, J, Tsianakas, A, Tenbrock, K, Rattenholl, A, Seeliger, S, Mack, M, Roth, J and Sunderkoetter, C. Glucocorticoids induce an activated, anti-inflammatory monocyte subset in mice that resembles myeloid-derived suppressor cells. J Leukoc Biol 2008. 84: 644-650.
99. Yahiaoui, L, Gvozdic, D, Danialou, G, Mack, M and Petrof, BJ. CC family chemokines directly regulate myoblast responses to skeletal muscle injury. J Physiol 2008. 586: 3991-4004.
100. Binder, NB, Niederreiter, B, Hoffmann, O, Stange, R, Pap, T, Stulnig, TM, Mack, M, Erben, RG, Smolen, JS and Redlich, K. Estrogen-dependent and C-C chemokine receptor-2-dependent pathways determine osteoclast behavior in osteoporosis. Nat Med 2009. 15: 417-424.
101. Cruickshank, SM, Deschoolmeester, ML, Svensson, M, Howell, G, Bazakou, A, Logunova, L, Little, MC, English, N, Mack, M, Grencis, RK, Else, KJ and Carding, SR. Rapid dendritic cell mobilization to the large intestinal epithelium is associated with resistance to Trichuris muris infection. J Immunol 2009. 182: 3055-3062.
102. Dagkalis, A, Wallace, C, Xu, H, Liebau, S, Manivannan, A, Stone, MA, Mack, M, Liversidge, J and Crane, IJ. Development of experimental autoimmune uveitis: efficient recruitment of monocytes is independent of CCR2. Invest Ophthalmol Vis Sci 2009. 50: 4288-4294.
103. Egan, C, Craven, M, Leng, J, Mack, M, Simpson, K and Denkers, E. CCR2-dependent intraepithelial lymphocytes mediate inflammatory gut pathology during Toxoplasma gondii infection. Mucosal Immunol 2009. doi:10.1038/mi.2009.105
104. Mildner, A, Mack, M, Schmidt, H, Bruck, W, Djukic, M, Zabel, MD, Hille, A, Priller, J and Prinz, M. CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system. Brain 2009. 132: 2487-2500.
105. Shechter, R, London, A, Varol, C, Raposo, C, Cusimano, M, Yovel, G, Rolls, A, Mack, M, Pluchino, S, Martino, G, Jung, S and Schwartz, M. Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice. PLoS Med 2009. 6: 1-17.
106. Hohl, TM, Rivera, A, Lipuma, L, Gallegos, A, Shi, C, Mack, M and Pamer, EG. Inflammatory monocytes facilitate adaptive CD4 T cell responses during respiratory fungal infection. Cell Host Microbe 2009. 6: 470-481.
107. Svensson, M, Russell, K, Mack, M and Else, KJ. CD4+ T-cell localization to the large intestinal mucosa during Trichuris muris infection is mediated by G alpha i-coupled receptors but is CCR6- and CXCR3-independent. Immunology 2010.129:257-67.
108. Gupta, S, Rieder, S, Richter, R, Schulz-Maronde, S, Manns, J, Escher, SE, Heitland, A, Mack, M, Forssmann, WG, Elsner, J and Forssmann, U. CCR1- and CCR5-mediated inactivation of leukocytes by a nonglycosaminoglycan (non-GAG)-binding variant of n-Nonanoyl-CCL14 (NNY-CCL14). J Leukoc Biol 2010, 1938-3673.
109. Herbold, W, Maus, R, Hahn, I, Ding, N, Srivastava, M, Christman, JW, Mack, M, Reutershan, J, Briles, DE, Paton, JC, Winter, C, Welte, T and Maus, UA. Importance of CXC chemokine receptor 2 in alveolar neutrophil and exudate macrophage recruitment in response to pneumococcal lung infection. Infect Immun 2010. 78: 2620-2630.
110. Movahedi, K, Laoui, D, Gysemans, C, Baeten, M, Stange, G, Van den Bossche, J, Mack, M, Pipeleers, D, In't Veld, P, De Baetselier, P and Van Ginderachter, JA. Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes. Cancer Res 2010. 70: 5728-5739.
111. Ksiazkiewicz, M, Gottfried, E, Kreutz, M, Mack, M, Hofstaedter, F, Kunz-Schughart, LA. Importance of CCL2-CCR2A/2B signaling for monocyte migration into spheroids of breast cancer-derived fibroblasts. Immunobiology. 2010. 215:737-47.
112. Egan, CE, Maurer, KJ, Cohen, SB, Mack, M, Simpson, KW and Denkers, EY. Synergy between intraepithelial lymphocytes and lamina propria T cells drives intestinal inflammation during infection. Mucosal Immunol 2011. 4: 658-670.
113. Jungbauer, CG, Birner, C, Jung, B, Buchner, S, Lubnow, M, von Bary, C, Endemann, D, Banas, B, Mack, M, Boger, CA, Riegger, G and Luchner, A. Kidney injury molecule-1 and N-acetyl-beta-D-glucosaminidase in chronic heart failure: possible biomarkers of cardiorenal syndrome. Eur J Heart Fail 2011. 13: 1104-1110.
114. Kurotaki, D, Kon, S, Bae, K, Ito, K, Matsui, Y, Nakayama, Y, Kanayama, M, Kimura, C, Narita, Y, Nishimura, T, Iwabuchi, K, Mack, M, van Rooijen, N, Sakaguchi, S, Uede, T and Morimoto, J. CSF-1-dependent red pulp macrophages regulate CD4 T cell responses. J Immunol 2011. 186: 2229-2237.
115. London, A, Itskovich, E, Benhar, I, Kalchenko, V, Mack, M, Jung, S and Schwartz, M. Neuroprotection and progenitor cell renewal in the injured adult murine retina requires healing monocyte-derived macrophages. J Exp Med 2011. 208: 23-39.
116. Miranda-Hernandez, S, Gerlach, N, Fletcher, JM, Biros, E, Mack, M, Korner, H and Baxter, AG. Role for MyD88, TLR2 and TLR9 but Not TLR1, TLR4 or TLR6 in Experimental Autoimmune Encephalomyelitis. J Immunol 2011. PMID: 21685327.
117. Fromm, PD, Kling, J, Mack, M, Sedgwick, JD and Korner, H. Loss of TNF Signaling Facilitates the Development of a Novel Ly-6Clow Macrophage Population Permissive for Leishmania major Infection. J Immunol 2012. 188: 6258-6266.
118. Hucke, S, Flossdorf, J, Grutzke, B, Dunay, IR, Frenzel, K, Jungverdorben, J, Linnartz, B, Mack, M, Peitz, M, Brustle, O, Kurts, C, Klockgether, T, Neumann, H, Prinz, M, Wiendl, H, Knolle, P and Klotz, L. Licensing of myeloid cells promotes central nervous system autoimmunity and is controlled by peroxisome proliferator-activated receptor gamma. Brain 2012. 135: 1586-1605.
119. Severin, IC, Souza, AL, Davis, JH, Musolino, N, Mack, M, Power, CA and Proudfoot, AE. Properties of 7ND-CCL2 are modulated upon fusion to Fc. Protein Eng Des Sel 2012. 25: 213-222.
120. Dhaliwal, K, Scholefield, E, Ferenbach, D, Gibbons, M, Duffin, R, Dorward, DA, Morris, AC, Humphries, D, MacKinnon, A, Wilkinson, TS, Wallace, WA, van Rooijen, N, Mack, M, Rossi, AG, Davidson, DJ, Hirani, N, Hughes, J, Haslett, C and Simpson, AJ. Monocytes control second-phase neutrophil emigration in established lipopolysaccharide-induced murine lung injury. Am J Respir Crit Care Med 2012. 186: 514-524.
121. Majer, O, Bourgeois, C, Zwolanek, F, Lassnig, C, Kerjaschki, D, Mack, M, Muller, M and Kuchler, K. Type I interferons promote fatal immunopathology by regulating inflammatory monocytes and neutrophils during Candida infections. PLoS Pathog 2012. 8: e1002811.
122. Mishra, MK, Wang, J, Silva, C, Mack, M and Yong, VW. Kinetics of proinflammatory monocytes in a model of multiple sclerosis and its perturbation by laquinimod. Am J Pathol 2012. 181: 642-651.
123. Wang, B, Zinselmeyer, BH, Runnels, HA, Labranche, TP, Morton, PA, Kreisel, D, Mack, M, Nickerson-Nutter, C, Allen, PM and Miller, MJ. In vivo imaging implicates CCR2(+) monocytes as regulators of neutrophil recruitment during arthritis. Cell Immunol 2012. 278: 103-112.
124. Zigmond, E, Varol, C, Farache, J, Elmaliah, E, Satpathy, AT, Friedlander, G, Mack, M, Shpigel, N, Boneca, IG, Murphy, KM, Shakhar, G, Halpern, Z and Jung, S. Ly6C(hi) Monocytes in the Inflamed Colon Give Rise to Proinflammatory Effector Cells and Migratory Antigen-Presenting Cells. Immunity 2012. 37: 1076-1090.
125. Avraham-Davidi, I, Yona, S, Grunewald, M, Landsman, L, Cochain, C, Silvestre, JS, Mizrahi, H, Faroja, M, Strauss-Ayali, D, Mack, M, Jung, S and Keshet, E. On-site education of VEGF-recruited monocytes improves their performance as angiogenic and arteriogenic accessory cells. J Exp Med 2013. 210: 2611-2625.
126. Kling, JC, Mack, M and Korner, H. The Absence of CCR7 Results in Dysregulated Monocyte Migration and Immunosuppression Facilitating Chronic Cutaneous Leishmaniasis. PLoS One 2013. 8: e79098.
127. Liu, J, Copland, DA, Horie, S, Wu, WK, Chen, M, Xu, Y, Paul Morgan, B, Mack, M, Xu, H, Nicholson, LB and Dick, AD. Myeloid cells expressing VEGF and arginase-1 following uptake of damaged retinal pigment epithelium suggests potential mechanism that drives the onset of choroidal angiogenesis in mice. PLoS One 2013. 8: e72935.
128. London, A, Benhar, I, Mattapallil, MJ, Mack, M, Caspi, RR and Schwartz, M. Functional macrophage heterogeneity in a mouse model of autoimmune central nervous system pathology. J Immunol 2013. 190: 3570-3578.
129. McElrath, MJ, Smythe, K, Randolph-Habecker, J, Melton, KR, Goodpaster, TA, Hughes, SM, Mack, M, Sato, A, Diaz, G, Steinbach, G, Novak, RM, Curlin, ME, Lord, JD, Maenza, J, Duerr, A, Frahm, N and Hladik, F. Comprehensive assessment of HIV target cells in the distal human gut suggests increasing HIV susceptibility toward the anus. J Acquir Immune Defic Syndr 2013. 63: 263-271.
130. Ribes, S, Regen, T, Meister, T, Tauber, SC, Schutze, S, Mildner, A, Mack, M, Hanisch, UK and Nau, R. Resistance of the Brain to Escherichia coli K1 Infection Depends on MyD88 Signaling and the Contribution of Neutrophils and Monocytes. Infect Immun 2013. 81: 1810-1819.
131. Schiechl, G, Brunner, SM, Kesselring, R, Martin, M, Ruemmele, P, Mack, M, Hirt, SW, Schlitt, HJ, Geissler, EK and Fichtner-Feigl, S. Inhibition of Innate Co-Receptor TREM-1 Signaling Reduces CD4(+) T Cell Activation and Prolongs Cardiac Allograft Survival. Am J Transplant 2013. 13: 1168-1180.
132. Bischof, A, Brumshagen, C, Ding, N, Kirchhof, G, Briles, DE, Gessner, JE, Welte, T, Mack, M and Maus, UA. Basophil expansion protects against invasive pneumococcal disease in mice. J Infect Dis 2014. 210: 14-24.
133. Ding, ZC, Lu, X, Yu, M, Lemos, H, Huang, L, Chandler, P, Liu, K, Walters, M, Krasinski, A, Mack, M, Blazar, BR, Mellor, AL, Munn, DH and Zhou, G. Immunosuppressive myeloid cells induced by chemotherapy attenuate antitumor CD4+ T-cell responses through the PD-1-PD-L1 axis. Cancer Res 2014. 74: 3441-3453.
134. Hammond, MD, Taylor, RA, Mullen, MT, Ai, Y, Aguila, HL, Mack, M, Kasner, SE, McCullough, LD and Sansing, LH. CCR2+ Ly6C(hi) inflammatory monocyte recruitment exacerbates acute disability following intracerebral hemorrhage. J Neurosci 2014. 34: 3901-3909.
135. Mitchell, CM, McLemore, L, Westerberg, K, Astronomo, R, Smythe, K, Gardella, C, Mack, M, Magaret, A, Patton, D, Agnew, K, McElrath, MJ, Hladik, F and Eschenbach, D. Long-term effect of depot medroxyprogesterone acetate on vaginal microbiota, epithelial thickness and HIV target cells. J Infect Dis 2014. 210: 651-655.
136. Newson, J, Stables, M, Karra, E, Arce-Vargas, F, Quezada, S, Motwani, M, Mack, M, Yona, S, Audzevich, T and Gilroy, DW. Resolution of acute inflammation bridges the gap between innate and adaptive immunity. Blood 2014. 124: 1748-1764.
137. Willemen, HL, Eijkelkamp, N, Garza Carbajal, A, Wang, H, Mack, M, Zijlstra, J, Heijnen, CJ and Kavelaars, A. Monocytes/Macrophages control resolution of transient inflammatory pain. J Pain 2014. 15: 496-506.
138. Biswas, A, Bruder, D, Wolf, SA, Jeron, A, Mack, M, Heimesaat, MM and Dunay, IR. Ly6Chigh Monocytes Control Cerebral Toxoplasmosis. J Immunol 2015. 194: 3223-3235.
139. Goritzka, M, Makris, S, Kausar, F, Durant, LR, Pereira, C, Kumagai, Y, Culley, FJ, Mack, M, Akira, S and Johansson, C. Alveolar macrophage-derived type I interferons orchestrate innate immunity to RSV through recruitment of antiviral monocytes. J Exp Med 2015. 212: 699-714.
140. Schumak, B, Klocke, K, Kuepper, JM, Biswas, A, Djie-Maletz, A, Limmer, A, van Rooijen, N, Mack, M, Hoerauf, A and Dunay, IR. Specific depletion of Ly6C(hi) inflammatory monocytes prevents immunopathology in experimental cerebral malaria. PLoS One 2015. 10: e0124080.
141. Singh, P, Dejager, L, Amand, M, Theatre, E, Vandereyken, M, Zurashvili, T, Singh, M, Mack, M, Timmermans, S, Musumeci, L, Dejardin, E, Mustelin, T, Van Ginderachter, JA, Moutschen, M, Oury, C, Libert, C and Rahmouni, S. DUSP3 Genetic Deletion Confers M2-like Macrophage-Dependent Tolerance to Septic Shock. J Immunol 2015. 194: 4951-4962.
142. Kara, EE, McKenzie, DR, Bastow, CR, Gregor, CE, Fenix, KA, Ogunniyi, AD, Paton, JC, Mack, M, Pombal, DR, Seillet, C, Dubois, B, Liston, A, MacDonald, KP, Belz, GT, Smyth, MJ, Hill, GR, Comerford, I and McColl, SR. CCR2 defines in vivo development and homing of IL-23-driven GM-CSF-producing Th17 cells. Nat Commun 2015. 6: 8644.
143. Moyat, M, Mack, M, Bouzourene, H and Velin, D. Role of Inflammatory Monocytes in Vaccine-Induced Reduction of Helicobacter felis Infection. Infect Immun 2015. 83: 4217-4228.
144. Song, C, Lee, JS, Gilfillan, S, Robinette, ML, Newberry, RD, Stappenbeck, TS, Mack, M, Cella, M and Colonna, M. Unique and redundant functions of NKp46+ ILC3s in models of intestinal inflammation. J Exp Med 2015. 212: 1869-1882.
145. Bain, CC, Hawley, CA, Garner, H, Scott, CL, Schridde, A, Steers, NJ, Mack, M, Joshi, A, Guilliams, M, Mowat, AM, Geissmann, F and Jenkins, SJ. Long-lived self-renewing bone marrow-derived macrophages displace embryo-derived cells to inhabit adult serous cavities. Nat Commun 2016. doi: 10.1038/ncomms11852.
146. Bonavita, O, Massara, M, Anselmo, A, Somma, P, Bruhl, H, Mack, M, Locati, M and Bonecchi, R. Flow Cytometry Detection of Chemokine Receptors for the Identification of Murine Monocyte and Neutrophil Subsets. Methods Enzymol 2016. 570: 441-456. doi: 10.1016/bs.mie.2015.09.011.
147. Channappanavar, R, Fehr, AR, Vijay, R, Mack, M, Zhao, J, Meyerholz, DK and Perlman, S. Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice. Cell Host Microbe 2016. 19: 181-193.
148. Evers, BD, Engel, DR, Bohner, AM, Tittel, AP, Krause, TA, Heuser, C, Garbi, N, Kastenmuller, W, Mack, M, Tiegs, G, Panzer, U, Boor, P, Ludwig-Portugall, I and Kurts, C. CD103+ Kidney Dendritic Cells Protect against Crescentic GN by Maintaining IL-10-Producing Regulatory T Cells. J Am Soc Nephrol 2016. pii: ASN.2015080873.
149. Liu, J, Copland, DA, Theodoropoulou, S, Chiu, HA, Barba, MD, Mak, KW, Mack, M, Nicholson, LB and Dick, AD. Impairing autophagy in retinal pigment epithelium leads to inflammasome activation and enhanced macrophage-mediated angiogenesis. Sci Rep 2016. 6: 20639. doi: 10.1038/srep20639.
150. Zimmermann, J, Kuhl, AA, Weber, M, Grun, JR, Loffler, J, Haftmann, C, Riedel, R, Maschmeyer, P, Lehmann, K, Westendorf, K, Mashreghi, MF, Lohning, M, Mack, M, Radbruch, A and Chang, HD. T-bet expression by Th cells promotes type 1 inflammation but is dispensable for colitis. Mucosal Immunol 2016. doi: 10.1038/mi.2016.5.
1. Kufer, P., M. Mack, R. Gruber, R. Lutterbüse, F. Zettl, and G. Riethmüller. 1997. Construction and biological activity of a recombinant bispecific single-chain antibody designed for therapy of minimal residual colorectal cancer. Cancer Immunol Immunother 45:193-197.
2. Kramer, B. K., C. Boger, B. Kruger, J. Marienhagen, M. Pietrzyk, A. Obed, L. Paczek, M. Mack, and B. Banas. 2005. Cardiovascular risk estimates and risk factors in renal transplant recipients. Transplant Proc 37:1868-1870.
3. Kramer, B. K., B. Kruger, M. Mack, A. Obed, B. Banas, L. Paczek, and H. J. Schlitt. 2005. Steroid withdrawal or steroid avoidance in renal transplant recipients: focus on tacrolimus-based immunosuppressive regimens. Transplant Proc 37:1789-1791.
4. Quinones, M. P., C. A. Estrada, Y. Kalkonde, S. K. Ahuja, W. A. Kuziel, M. Mack, and S. S. Ahuja. 2005. The complex role of the chemokine receptor CCR2 in collagen-induced arthritis: implications for therapeutic targeting of CCR2 in rheumatoid arthritis. J Mol Med 83:672-681.
5. Mack, M. 2006. Uptake of Microparticles by B cells. Mod. Asp Immunobiol. 19:13-14.
6. Mack, M. Podocyte antigens, dendritic cells and T cells contribute to renal injury in newly developed mouse models of glomerulonephritis. Nephrol Dial Transplant 2009. 24: 2984-2986.
7. Mack, M and Rosenkranz, AR. Basophils and mast cells in renal injury. Kidney Int 2009. 76: 1142-1147.
8. Mack, M, Niedermeier, M and Reich, B. Immunregulation of Fibrocyte Differentiation. Chapter 5 in "Fibrocytes in Health and Disease". World Scientific Publishing 2012: 53-72.
9. Mack, M and Yanagita, M. Origin of myofibroblasts and cellular events triggering fibrosis. Kidney Int 2015. 87: 297-307.
10. Mack, M. Leukocyte derived microvesicel dock on glomerular endothelial cells: stardust in the kidney. Kidney Int. 2017. 91:13-15
1. Antibody and chemokine constructs and their use in the treatment of infections or immunological diseases: PCT/EP 00/02154 und EP1317284A2
2. Mono-and dual anti-CD4-RANTES chemokine/cytokine constructs: EP1456241A2
3. Treatment of multiple sclerosis and/or rheumatoid arthritis: WO2007/115713
4. IL-3 inhibitors in use for treatment of rheumatoid arthritis in an early stage: EP08021114.7
5. Novel IL-3 antibodies and their use in diagnosis and treatment of diseases or malfunctions associated with elevated levels of IL-3: EP12169799.9
6. Diagnostic method for determining the presence and amount of human interleukin-3 in a sample using novel IL-3 antibodies: EP12169805.4
7. IL-3 blockade in systemic lupus erythematosus and multiple sclerosis: EP 2868328 A1
8. Novel blocking IL-3 antibodies B75198
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