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Klinik und Poliklinik für Innere Medizin III
Hämatologie und Internistische Onkologie

Hansmann Lab

Experimental Tumor Immunology

We study the human immune system with a focus on T and B cell biology in the context of hematopoietic and solid malignancies. We are especially interested in the cues that drive clonal lymphocyte expansion and how malignancies can evade cellular immune responses. Our single cell technologies for T cell receptor and immunoglobulin sequencing in combination with high-dimensional phenotyping and functional profiling give insights into specificities and functional states of immune cells in context of cancer and autoimmune diseases.

Our goal is to identify and understand cancer-directed immune responses in order to

  1. develop supportive strategies to immunologically eradicate cancer.
  2. use these as highly sensitive and specific tumor markers.
  3. design targeted (cellular) therapeutics.

 

Another focus relies in the understanding of T-cell immunology in context of viral infections, bone marrow failure syndromes, autoimmune diseases, allogeneic stem cell transplantation, and CAR-T-cell therapy. Our findings will help to develop cellular therapeutics for induction of organ- or antigen-specific immunosuppression.

  • Research Areas
    • Tumor immunology
    • Infection immunology
    • Autoimmune diseases
    • Lymphocyte differentiation and function
    • Single cell technologies

  • Selected Publications
    • Ben Hamza, A., Welters, C., Stadler, S., Bruggemann, M., Dietze, K., Brauns, O., Brummendorf, T. H., Winkler, T., Bullinger, L., Blankenstein, T., Rosenberger, L., Leisegang, M., Kammertons, T., Herr, W., Moosmann, A., Strobel, J., Hackstein, H., Dornmair, K., Beier, F. and Hansmann, L., Virus-reactive T cells expanded in aplastic anemia eliminate hematopoietic progenitor cells by molecular mimicry. Blood 2024. 143: 1365-1378.
    • Welters, M. L., Stadler, S., Anastasopoulou, V., Bullinger, L., Leisegang, M., Kammertons, T., Welters, C. and Hansmann, L., Oligonucleotide library screening for identification of virus-specific T-cell receptors. Eur J Immunol 2024. 54: e2350908.
    • Welters, C., Welters, M. L., Stadler, S., Bullinger, L., Strobel, J., Hackstein, H., Dhamodaran, A., Blankenstein, T. and Hansmann, L., HLA-C*04:09N is expressed at the cell surface and triggers peptide-specific T-cell activation. Haematologica 2024. 109: 1121-1127.
    • Ballhausen, A., Ben Hamza, A., Welters, C., Dietze, K., Bullinger, L., Rahn, H. P., Hartmann, S., Hansmann, M. L. and Hansmann, L., Immune phenotypes and checkpoint molecule expression of clonally expanded lymph node-infiltrating T cells in classical Hodgkin lymphoma. Cancer Immunol Immunother 2023. 72: 515-521.
    • Lammoglia Cobo, M. F., Welters, C., Rosenberger, L., Leisegang, M., Dietze, K., Pircher, C., Penter, L., Gary, R., Bullinger, L., Takvorian, A., Moosmann, A., Dornmair, K., Blankenstein, T., Kammertons, T., Gerbitz, A. and Hansmann, L., Rapid single-cell identification of Epstein-Barr virus-specific T-cell receptors for cellular therapy. Cytotherapy 2022. 24: 818-826.
    • Welters, C., Lammoglia Cobo, M. F., Stein, C. A., Hsu, M. T., Ben Hamza, A., Penter, L., Chen, X., Buccitelli, C., Popp, O., Mertins, P., Dietze, K., Bullinger, L., Moosmann, A., Blanc, E., Beule, D., Gerbitz, A., Strobel, J., Hackstein, H., Rahn, H. P., Dornmair, K., Blankenstein, T. and Hansmann, L., Immune Phenotypes and Target Antigens of Clonally Expanded Bone Marrow T Cells in Treatment-Naive Multiple Myeloma. Cancer Immunol Res 2022. 10: 1407-1419.
    • Penter, L., Dietze, K., Ritter, J., Lammoglia Cobo, M. F., Garmshausen, J., Aigner, F., Bullinger, L., Hackstein, H., Wienzek-Lischka, S., Blankenstein, T., Hummel, M., Dornmair, K. and Hansmann, L., Localization-associated immune phenotypes of clonally expanded tumor-infiltrating T cells and distribution of their target antigens in rectal cancer. Oncoimmunology 2019. 8: e1586409.

Contact information

Prof. Dr. med. Leo Hansmann
Universitätsklinikum Regensburg
Klinik und Poliklinik für Innere Medizin III
Franz-Josef-Strauß-Allee 11
93053 Regensburg
leo.hansmann@ukr.de